Toxic epidermal necrolysis (TEN) is a potentially lifethreatening skin disorder that is most commonly seen secondary to a drug reaction.
In this condition the skin develops a scalded appearance over an extensive area. Some authors consider TEN to be the severe end of a spectrum of skin disorders which includes erythema multiforme and Stevens Johnson syndrome
- systemically unwell e.g. pyrexia, tachycardic
- positive Nikolsky's sign: the epidermis separates with mild lateral pressure
Drugs known to induce Toxic epidermal necrolysis (TEN)
- stop precipitating factor
- supportive care, often in intensive care unit
- intravenous immunoglobulin has been shown to be effective and is now commonly used as first line treatment.
- other treatment options include: immunosuppressive agents (ciclosporin an cyclophosphamide),