Saturday, November 12, 2016

A 45 Year Old Man With Hyperpigmented Skin In The Arm Pit

A 45 year old man has hyperpigmented skin in the arm pit ( picture shown below).

                                              Acanthosis nigricans

Which of the following malignancies is associated with the skin condition shown here?
A) Ovarian carcinoma
B) Gastric carcinoma
C) Malignant melanoma
D) Multiple myeloma
E) Hodgkin’s lymphoma

The answer is
B. (Gastric carcinoma)

Discussion: Acanthosis nigricans is associated with hyperpigmented areas that typically affect flexural folds (axilla). The two basic types of acanthosis nigricans are benign and malignant.
The benign form is associated with :

  • obesity, 
  • diabetes, 
  • Stein–Leventhal syndrome,
  • Cushing’s disease, 
  • Addison’s disease, 
  • pituitary disorders, and
  • hyperandrogenic syndromes. 
  • Drugs, including glucocorticoids, nicotinic acid, diethylstilbestrol, and growth hormone therapy, have also caused acanthosis nigricans. 
  • Many cases are idiopathic. 

Malignant acanthosis nigricans is associated with an intestinal cancer such as gastric carcinoma.

1 comment:

  1. Hello, my name is Betty. i was diagnosed of HIV virus 4 years back. Before then, i was dating this Derrick guy. we had something great going on. Our love life only lasted for 8 months. the sixth and seven month of our relationship, i began feeling very weak every now and then. But i never suspected anything until I kept on experiencing different symptoms like having sore throats, constant headache, body weakness e.t.c. I decided to go for a medical check up. I was tested HIV positive. when the doctor broke the news to me, it was as if my whole world had crumbled. it dawned on me then that Derrick has been lying to me. i was very mad to an extent i almost committed suicide. But there was nothing i could do, other than weep and weep. ever since then, i have been spending heavily on medications, going from one medical clinic or the other so I can look healthy. Though since i was a kid, i love herbs a lot. i take herbal tea with grandma while growing so i am quite familiar with herbs. early last year, i was on the internet and on a particular health blog, to check for herbal medication as alternative. I saw many comments and read many testimonies. Until i came across a particular testimony on how Dr.ugo cured a patient from herpes simplex virus using pure natural herbs. i reached out to the doctor because I also was thinking Herpes had no cure. I told him about my HIV status.He encouraged me not to panic that he will help me get my deliverance. he prepared some herbs and sent them to me. The herbs were in four 70ml bottles and I took them morning and night. i used as he directed, and in less than three weeks, i started having appetite to eat plenty of food and i gained back my strength. the fourth week,I consumed all the herbal meds. He encouraged me to go for a test which i did. This time, the result was negative. I quickly contacted the doctor and informed him of the news. I immediately asked him to prepare for Derrick too. He did and sent it. Today, me and Derrick are HIV free. All thanks goes to God Almighty for healing us through Dr.Ugo. if you are having any kind of sickness at all, Dr.Ugo is the right person to talk to and i assure you, you will be glad you did. His email: you can also write him on WhatsApp +2348104990619.