Saturday, November 12, 2016

A 45 Year Old Man With Hyperpigmented Skin In The Arm Pit

A 45 year old man has hyperpigmented skin in the arm pit ( picture shown below).

                                              Acanthosis nigricans

Which of the following malignancies is associated with the skin condition shown here?
A) Ovarian carcinoma
B) Gastric carcinoma
C) Malignant melanoma
D) Multiple myeloma
E) Hodgkin’s lymphoma

The answer is
B. (Gastric carcinoma)

Discussion: Acanthosis nigricans is associated with hyperpigmented areas that typically affect flexural folds (axilla). The two basic types of acanthosis nigricans are benign and malignant.
The benign form is associated with :

  • obesity, 
  • diabetes, 
  • Stein–Leventhal syndrome,
  • Cushing’s disease, 
  • Addison’s disease, 
  • pituitary disorders, and
  • hyperandrogenic syndromes. 
  • Drugs, including glucocorticoids, nicotinic acid, diethylstilbestrol, and growth hormone therapy, have also caused acanthosis nigricans. 
  • Many cases are idiopathic. 

Malignant acanthosis nigricans is associated with an intestinal cancer such as gastric carcinoma.

1 comment:

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