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Saturday, May 6, 2017

Introduction to Dermatophytosis



Introduction
Also called tinea or ringworm, dermatophytosis is a disease that can affect the scalp (tinea capitis), body (tinea corporis), nails (tinea unguium), feet (tinea pedis), groin (tinea cruris), and bearded skin (tinea barbae).
Tinea infections are quite prevalent in the United States and are usually more common in males than in females. With effective treatment, the cure rate is very high, although about 20% of persons with infected feet or nails develop chronic conditions.

Causes
Tinea infections (except for tinea versicolor) result from dermatophytes (noncandidal fungi) of the genera Trichophyton, Microsporum, and Epidermophyton that involve the stratum corneum, nails or hair.
Transmission can occur directly (through contact with infected lesions) or indirectly (through contact with contaminated articles, such as shoes, towels, or shower stalls). Some cases come from animals or soil.

Signs and symptoms
Lesions vary in appearance and duration with the type of infection:
Tinea capitis, which mainly affects children, is characterized by round erythematous patches on the scalp, causing hair loss with scaling. In some children, a hypersensitivity reaction develops, leading to boggy, inflamed, commonly pus-filled lesions (kerions).
Tinea corporis produces flat lesions on the skin at any site except the scalp, bearded skin, groin, palms, or soles. These lesions may be dry and scaly or moist and crusty; as they enlarge, their centers heal, causing the classic ring-shaped appearance.
Tinea unguium (onychomycosis) infection typically starts at the tip of one or more toenails (fingernail infection is less common) and produces gradual thickening, discoloration, and crumbling of the nail, with accumulation of subungual debris. Eventually, the nail may be destroyed completely.
Tinea pedis causes scaling and blisters between the toes. Severe infection may result in inflammation, with severe itching and pain on walking. A dry, squamous inflammation may affect the entire sole.
Tinea cruris (jock itch) produces red, raised, sharply defined, itchy lesions in the groin that may extend to the buttocks, inner thighs, and the external genitalia. Warm weather and tight clothing encourage fungus growth.
Tinea barbae is an uncommon infection that affects the bearded facial area of men.
Diagnosis
Microscopic examination of lesion scrapings prepared in 10% to 20% potassium hydroxide solution usually confirms tinea infection. Other diagnostic procedures include Wood’s light examination (which is useful in only about 5% of cases of tinea capitis) and culture of the infecting organism.

Treatment
  • Tinea infections usually respond to topical agents such as imidazole cream or to oral griseofulvin, which is especially effective in tinea infections of the skin and hair. 
  • Oral terbinafine or itraconazole is helpful in nail infections.
  • However, topical therapy is ineffective for tinea capitis; oral griseofulvin for 1 to 3 months is the treatment of choice.
  • In addition to imidazole, other antifungals include naftifine, ciclopirox, terbinafine, haloprogin, and tolnaftate. Topical treatments should continue for 2 weeks after lesions resolve.
  • Supportive measures include open wet dressings, removal of scabs and scales, and application of keratolytics such as salicylic acid to soften and remove hyperkeratotic lesions of the heels or soles.

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